Pain Ease®: Topical Anesthetic Skin Refrigerant


Pain Ease® spray is a vapocoolant (skin refrigerant) intended for topical application to skin and minor open wounds. It controls pain associated with injections (venipunctures, IV start) and minor surgical procedures (eg. irrigating laceration/abrasions).


Can be used in patients 4 years and older (has not been tested in younger children).

Pain Ease is contraindicated for use in immunocompromised patients or prior to drawing blood culture specimens as the contents of the can are not sterile.


  1. IDENTIFY patient and EXPLAIN procedure. Prepare patient for what to expect: "it's cold, will drip and will numb the skin."

Failure to correctly identify patients prior to procedures may result in errors.

Reduces child and family’s anxiety. Evaluates and reinforces understanding of information and confirms consent for treatment/procedure.

  1. PERFORM hand hygiene and PREPARE all necessary equipment for performing procedure.
Anesthetic effect lasts only up to 1 minute so it is necessary to be fully prepared for procedure before applying spray.
  1. SWAB venipuncture/injection site with alcohol/chlorhexidine swab and allow to dry.
Routine precautions; reduces transmission of microorganisms.
  1. SPRAY area with Pain Ease steadily for 4-10 seconds covering an area the size of a quarter from a distance of 8-18 cm (3-7 inches). STOP spraying when the skin starts to blanch or 10 seconds has elapsed, whichever comes first. Allow solution to dry completely.

The anesthetic effect is complete within 10 seconds or when blanching of the skin occurs

Attempting venipuncture when solution is still wet on the skin will cause pain as the needle punctures the skin and enters the vessel.

  1. PERFORM venipuncture/injection immediately. Spray may be reapplied as needed.
The anesthetic effect lasts up to 1 minute.


DOCUMENT in appropriate record(s):


Farion, K.J., Splinter, K.L., Newhook, K., Gaboury, .I and Splinter, W.M. (2008). The Effect of Vapocoolant Spray on Pain Due to Intravenous Cannulation in Children: A Randomized Controlled Trial. Canadian Medical Association Journal. 179(1):31-36.

Gebauer's Pain Ease® Product Information: Indications and Use. Retrieved from:

Stone, S. and Maugh, E. (2008). Using Pain Ease for Topical Analgesia in Children. Emergency Medicine. 40(10):Suppl 1-4.

CC.06.21 BC Children’s Hospital Child & Youth Health Policy and Procedure Manual Page 2 of 2